The mission of the TNU is to develop and validate mathematical models for inferring subject-specific mechanisms of brain diseases from non-invasive measures of neuronal activity and behaviour.  The hope is that model-based quantification of disease processes will help establishing novel diagnostic procedures, enable the redefinition of psychiatric spectrum diseases (such as schizophrenia, depression or autism) and provide treatment predictions for individual patients.

The history of the TNU began in December 2011 when its founding director, Klaas Enno Stephan, was jointly appointed by the University of Zurich (UZH) and ETH Zurich as Professor of Translational Neuromodeling at the Institute of Biomedical Engineering.  The TNU obtained its home in July 2012 when the group moved into a UZH building at Wilfriedstr. 6. This building underwent reconstruction in order to provide a unique research space which integrates computational scientists and clinicians under one roof and provides a custom-designed research clinic for evaluating the practical utility of computational models in patient studies.

At its foundation in 2012, the TNU consisted of only a handful of scientists; within a few years, we have grown to include more than 30 researchers, technicians and administrators. This has been made possible by the generous support of various institutions and foundations, including

  • UZH & ETH Zürich
  • René und Susanne Braginsky Stiftung
  • European Union FP7 program
  • Schweizerischer Nationalfonds (SNF)
  • Deutsche Forschungsgesellschaft (DFG)
  • NCCR „Neural Plasticity and Repair“
  • Zentrum für Neurowissenschaften Zürich (ZNZ)
  • SystemsX.ch – The Swiss Initiative in Systems Biology
  • Clinical Research Priority Program “Multiple Sclerosis” (CRPP-MS)
  • Clinical Research Priority Program “Molecular Imaging” (MINZ)

The TNU celebrated its Opening Symposium on 18-20 September 2013. For details of the event, click here.