Translational Neuromodeling Unit (TNU)

The TNU was established in 2012 as a joint Chair by the University of Zurich and ETH Zurich and forms a division of the Institute for Biomedical Engineering. The mission of the TNU is to develop and validate mathematical models for inferring subject-specific mechanisms of brain disease from non-invasive measures of behavior and neuronal activity. These models aim to quantify both physiological (synaptic) and computational (information processing) principles that underlie maladaptive cognition, such as aberrant learning and decision-making, in individual subjects.

The long-term goal is to establish novel diagnostic procedures that enable the redefinition of psychiatric spectrum diseases (such as schizophrenia, depression or autism) and provide treatment predictions for individual patients.


To achieve this goal, the TNU integrates computational scientists and clinicians under one roof and operates a research clinic for evaluating the clinical utility of neuromodeling procedures in patient studies.