Prof. Dr. Klaas Enno Stephan, MD Dr. med. PhD

Director Translational Neuromodeling Unit


Translational Neuromodeling Unit
Institute for Biomedical Engineering
University of Zurich and ETH Zurich
Klaas Enno Stephan
Wilfriedstrasse 6
8032 Zurich

Office:WIL G-203


Positions & Affiliations

Professor of Translational Neuromodeling, Institute for Biomedical Engineering, University of Zurich & ETH Zurich
Director, Translational Neuromodeling Unit (TNU), Zurich
Principal Investigator, Laboratory for Social and Neural Systems Research (SNS), University of Zurich
Honorary Principal, Wellcome Trust Centre for Neuroimaging, University College London
External Scientific Member, Max Planck Institute for Metabolism Research, Cologne


Klaas Enno Stephan is a computational neuroscientist and medical doctor. Following undergraduate studies in medicine, computer science and mathematics and the completion of his medical license, he obtained doctoral degrees in Medicine (Dr. med., Düsseldorf) and Neuroinformatics (PhD, Newcastle) and undertook postdoctoral training in computational neuroimaging at UCL (with Karl Friston). He was appointed Assistant Professor for Computational Neuroeconomics at the University of Zurich (UZH) in 2008, and Full Professor for Translational Neuromodeling at UZH and ETH Zurich in 2011. Additionally, he is Honorary Principal at the Wellcome Centre for Neuroimaging, London, and External Scientific Member of the Max Planck Institute for Metabolism Research, Cologne.

Klaas’ track record includes the development of the connectivity database CoCoMac and neuroinformatics tools for connectivity analyses (with Rolf Kötter), the development of widely used generative models for fMRI and Bayesian model selection techniques (with Karl Friston and Will Penny), and empirical and theoretical work on psychiatric disease mechanisms. His scientific work has been recognized by several awards and honours, including the Wiley Young Investigator Award for Human Brain Mapping and election to the Max Planck Society.

Klaas’ present work focuses on developing clinically useful “computational assays” for Computational Psychiatry and Computational Psychosomatics. Based on inferred disease mechanisms from brain activity and behavioural measurements, the hope is that such assays will support more precise diagnostics and individualized treatment recommendations, leading to a transformation of clinical practice and, eventually, a redefinition of mental diseases. Research foci include schizophrenia and psychosomatics (brain-body interactions in depression). In 2012, Klaas founded the Translational Neuromodeling Unit (TNU), an interdisciplinary institution with the explicit mission statement to translate advances in computational neuroscience into diagnostic tools for clinical practice. The TNU assembles computational scientists and clinicians under one roof and operates a dedicated research clinic for evaluating the diagnostic and prognostic utility of computational assays in prospective patient studies.

Publications & FAQ

Publication list (peer-reviewed journal articles)


Frequently Asked Questions