Prof. Dr. Klaas Enno Stephan

Director Translational Neuromodeling Unit


Translational Neuromodeling Unit
Institute for Biomedical Engineering
University of Zurich and ETH Zurich
Klaas Enno Stephan
Wilfriedstrasse 6
8032 Zurich

Office:WIL G-203


Positions & Affiliations

Professor of Translational Neuromodeling & Computational Psychiatry, Institute for Biomedical Engineering, University of Zurich & ETH Zurich
Director, Translational Neuromodeling Unit (TNU), Zurich
Honorary Principal, Wellcome Trust Centre for Neuroimaging, University College London
External Scientific Member, Max Planck Institute for Metabolism Research, Cologne


Klaas Enno Stephan is a computational neuroscientist and medical doctor. He is presently Full Professor at UZH and ETH Zurich where he holds the Chair of Translational Neuromodeling & Computational Psychiatry. Additionally, he is Honorary Principal at the Wellcome Centre for Neuroimaging, London, and External Scientific Member of the Max Planck Institute for Metabolism Research, Cologne.

Klaas’ track record includes the development of the connectivity database CoCoMac and neuroinformatics tools for connectivity analyses like Objective Relational Transformation (with Rolf Kötter), the development of widely used generative models for fMRI data and Bayesian model selection techniques (with Karl Friston and Will Penny), and empirical and theoretical work on psychiatric disease mechanisms.

Klaas’ present work focuses on developing clinically useful “computational assays” for Computational Psychiatry and Computational Psychosomatics. Based on inferred disease mechanisms from brain activity and behavioural measurements, the hope is that such assays will support more precise diagnostics and individualized treatment recommendations, leading to a transformation of clinical practice and, eventually, a redefinition of mental diseases. Past and ongoing studies in patients have concerned schizophrenia, depression, autism, pathological gambling, and multiple sclerosis. An ermerging new focus is on brain-body interactions in depression.

In 2012, Klaas founded the Translational Neuromodeling Unit (TNU) at Zurich, an interdisciplinary institution with the explicit mission statement to translate advances in computational neuroscience into diagnostic tools for clinical practice. The TNU assembles computational scientists and clinicians under one roof and operates a dedicated research clinic for evaluating the diagnostic and prognostic utility of computational assays in prospective patient studies.

Publications & FAQ

Publication list (peer-reviewed journal articles)


Frequently Asked Questions